About: Buprenorphine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Buprenorphine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Buprenorphine Hydrochloride
UMLS_CUI
  • C0006404
CAS_Registry
  • 53152-21-9
FDA_UNII_Code
  • 56W8MW3EN1
Contributing_Source
  • FDA
Chemical_Formula
  • C29H41NO4.HCl
Legacy_Concept_Name
  • Buprenorphine_Hydrochloride
CHEBI_ID
  • CHEBI:652822
FULL_SYN
  • 5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol HydrochlorideSNNCI
  • RX 6029-M HClCNNCI
  • Buprenorphine HydrochloridePTNCI
  • SubutexSYNCI
  • NIH 8805CNNCI
  • BuprenexBRNCI
  • BUPRENORPHINE HYDROCHLORIDEPTFDA56W8MW3EN1
DEFINITION
  • The hydrochloride salt form of buprenorphine, a synthetic phenanthrene with narcotic analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid receptor and an antagonist at the kapa-opioid receptor in the central nervous system. However, under the conditions of recommended use it behaves as a classic mu-opioid agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The agonist action results in a raised pain threshold and increased tolerance to pain. However, it also causes sedation, physical dependence, and respiratory depressant effects and decreases heart rate and blood pressure.NCI
code
  • C47424
is Has_Salt_Form of
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