About: Epirubicin Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Epirubicin Hydrochloride
rdfs:subClassOf	Anthracyclines
Has_Free_Acid_Or_Base_Form	EPIRUBICIN
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Epirubicin Hydrochloride
NSC_Code	256942
UMLS_CUI	C0701345
CAS_Registry	56390-09-1
Accepted_Therapeutic_Use_For	Breast cancer
In_Clinical_Trial_For	Breast cancer; chronic lymphocytic leukemia; endometrial cancer; esophageal cancer; gastric cancer; liver cancer; malignant mesenchymal cancer; mesothelioma; Non-Hodgkins lymphoma; small cell lung cancer; soft tissue sarcoma; unspecified solid tumors
FDA_UNII_Code	22966TX7J5
Contributing_Source	FDA
ALT_DEFINITION	A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Ellence is a type of anthracycline antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39232
PDQ_Closed_Trial_Search_ID	39232
Chemical_Formula	C27H29NO11.HCl
Legacy_Concept_Name	Epirubicin
FULL_SYN	epirubicin hydrochloridePTNCI-GLOSSCDR0000523457 Epirubicin HydrochloridePTNCI 3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside HydrochlorideSNNCI EPIRUBICIN HYDROCHLORIDEPTFDA22966TX7J5 (8S-cis)-10-[(-Amino-2,3,6-trideoxy-alpha-L-arabino-hexpyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxacetyl)-1-methoxy-5,12-naphthacenedione HydrochlorideSNNCI Pharmorubicin PFSFBNCI IMI-28CNNCI EllencePTNCI-GLOSSCDR0000523458 (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione HydrochlorideSNNCI EllenceBRNCI
DEFINITION	The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.NCI
code	C474
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is Has_Salt_Form of	EPIRUBICIN

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