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AttributesValues
rdf:type
rdfs:label
  • Acrivastine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Acrivastine
UMLS_CUI
  • C0054340
CAS_Registry
  • 87848-99-5
FDA_UNII_Code
  • A20F9XAI7W
Contributing_Source
  • FDA
Chemical_Formula
  • C22H24N2O2
Legacy_Concept_Name
  • Acrivastine
FULL_SYN
  • AcrivastinePTNCI
  • BW 825CCNNCI
  • SemprexBRNCI
  • 2-Propenoic Acid, 3-(6-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-2-pyridinyl)-,(E,E)-SNNCI
  • ACRIVASTINEPTFDAA20F9XAI7W
  • (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic AcidSNNCI
DEFINITION
  • A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05)NCI
code
  • C47383
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