About: Doxorubicin

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Attributes	Values
rdf:type	Class
rdfs:label	Doxorubicin
rdfs:subClassOf	Doxorubicin Preparation
Has_Salt_Form	Doxorubicin Hydrochloride
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Doxorubicin
UMLS_CUI	C0013089
CAS_Registry	23214-92-8
FDA_UNII_Code	80168379AG
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.NCI-GLOSS
Chemical_Formula	C27H29NO11
Legacy_Concept_Name	Doxorubicin
CHEBI_ID	CHEBI:28748
FULL_SYN	DoxorubicinSYDTPNSC0123127 DoxorubicinPTNCI (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedioneSNNCI DoxorubicinSYNCITCGA doxorubicinPTNCI-GLOSSCDR0000045140 (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedioneSNNCI 14-HydroxydaunomycinSNNCI DOXORUBICINPTFDA80168379AG HydroxyldaunorubicinSYNCI Hydroxyl DaunorubicinSYNCI
DEFINITION	An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.NCI
code	C456
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