About: Iron Dextran Complex     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Iron Dextran Complex
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Iron Dextran Complex
NSC_Code
  • 57682
UMLS_CUI
  • C0022092
CAS_Registry
  • 9004-66-4
PDQ_Open_Trial_Search_ID
  • 551718
PDQ_Closed_Trial_Search_ID
  • 551718
Legacy_Concept_Name
  • Iron_Dextran_Complex
FULL_SYN
  • Iron Dextran InjectionSYNCI
  • INFeDBRNCI
  • ImferonBRNCI
  • Iron Dextran ComplexPTNCI
  • DexferrumBRNCI
DEFINITION
  • A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation.NCI
code
  • C44394
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