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AttributesValues
rdf:type
rdfs:label
  • Diazoxide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Diazoxide
NSC_Code
  • 64198
  • 76130
UMLS_CUI
  • C0012022
CAS_Registry
  • 364-98-7
Accepted_Therapeutic_Use_For
  • Malignant Hypertension
FDA_UNII_Code
  • O5CB12L4FN
Contributing_Source
  • FDA
ALT_DEFINITION
  • A peripheral vasodilator that reduces blood pressure. Diazoxide also has antidiuretic and hypoglycemic effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p353)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39290
PDQ_Closed_Trial_Search_ID
  • 39290
Chemical_Formula
  • C8H7ClN2O2S
Legacy_Concept_Name
  • Diazoxide
CHEBI_ID
  • CHEBI:4495
FULL_SYN
  • DiazoxidePTDCP30277
  • DIAZOXIDEPTFDAO5CB12L4FN
  • SRG-95213CNNCI
  • DiazoxidePTNCI
  • ProglycemBRNCI
  • 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-DioxideSNNCI
DEFINITION
  • A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.NCI
code
  • C428
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