About: Melanocyte Protein Pmel 17     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Melanocyte Protein Pmel 17
rdfs:subClassOf
OMIM_Number
  • 155550
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Melanocyte Protein Pmel 17
UMLS_CUI
  • C0257766
Legacy_Concept_Name
  • Melanocyte_Lineage-Specific_Antigen-gp100
FULL_SYN
  • ME20M/ME20SSYNCI
  • Silver LikeSYNCI
  • ME20-M/ME20-SSYNCI
  • Melanocyte Protein MEL17SYNCI
  • SISYNCI
  • Melanocyte Protein PMEL17SYNCI
  • Silver HomologSYNCI
  • SILSYNCI
  • Melanocyte Protein Pmel 17PTNCI
  • ME20SYNCI
  • SILVSYNCI
  • ME20MSYNCI
  • gp100SYNCI
  • 95 kDa Melanocyte-Specific Secreted GlycoproteinSYNCI
  • ME20-MSYNCI
  • PMEL17SYNCI
  • Silver Locus Protein HomologSYNCI
  • Melanocyte Lineage-Specific Antigen gp100SYNCI
  • Melanoma-Associated ME20 AntigenSYNCI
Swiss_Prot
  • P40967
DEFINITION
  • Melanocyte protein Pmel 17 (661 aa, ~70 kDa) is encoded by the human SILV gene. This protein may be involved in melanogenesis.NCI
DesignNote
  • Expressed in melanocytes and melanomas by human SILV Gene (PMEL17/NMB Family), 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100is a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate.
code
  • C41037
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