About: Cytarabine

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Attributes	Values
rdf:type	Class
rdfs:label	Cytarabine
rdfs:subClassOf	Pyrimidine Antagonist
Has_Salt_Form	Cytarabine Hydrochloride
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Cytarabine
NSC_Code	287459
UMLS_CUI	C0010711
CAS_Registry	147-94-4
Accepted_Therapeutic_Use_For	Meningeal leukemia; Acute Myeloid Leukemia; Meningitis lymphomatous; Myelodysplasic syndrome; Non-Hodgkins lymphoma; Ovarian cancer, intraperitoneal treatment; Retinoblastoma Acute lymphocytic leukemia; Acute Nonlymphocytic leukemia; Bone marrow transplantation; Carcinomatous meningitis; Chronic myelogenous leukemia; Hogkins disease;
In_Clinical_Trial_For	Leukemia; Lymphoma; Meningeal Neoplasms
FDA_UNII_Code	04079A1RDZ
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39015
PDQ_Closed_Trial_Search_ID	39015
Chemical_Formula	C9H13N3O5
Legacy_Concept_Name	Cytosine_Arabinoside
CHEBI_ID	CHEBI:28680
FULL_SYN	AracytidineSYDTPNSC0287459 ArabinosylcytosineSYDTPNSC0287459 AracytidineSYNCI CytarabinumSYNCI cytarabinePTNCI-GLOSSCDR0000045155 1-Beta-D-arabinofuranosylcytosineSNNCI Tarabine PFSBRNCI .beta.-Cytosine arabinosideSYDTPNSC0287459 Cytosine-.beta.-arabinosideSYDTPNSC0287459 1.beta.-D-ArabinofuranosylcytosineSYDTPNSC0287459 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-SYDTPNSC0287459 ArabinofuranosylcytosineSYNCI U 19920SYDTPNSC0063878 Beta-Cytosine ArabinosideSYNCI 1-.beta.-D-ArabinofuranosylcytosineSYDTPNSC0287459 CytosarSYDTPNSC0287459 Ara-CABNCI Cytosine ArabinosidePTDCP01949 AlexanFBNCI UdicilFBNCI U-19920CNNCI ArabinosylcytosineSYNCI ArabineFBNCI ErpalfaFBNCI CytosarFBNCI CYTARABINEPTFDA04079A1RDZ CHX-3311CNNCI WR-28453CNNCI ARA-cellFBNCI CytarbelFBNCI AracytinFBNCI StarasidFBNCI ArabinofuranosylcytosineSYDTPNSC0287459 Cytosar-UBRNCI AracytineFBNCI 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinoneSNNCI CytarabinePTNCI 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinoneSYDTPNSC0287459
DEFINITION	An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)NCI
code	C408
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