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AttributesValues
rdf:type
rdfs:label
  • Negative Regulation of Degradation of Complement
rdfs:subClassOf
Semantic_Type
  • Physiologic Function
Preferred_Name
  • Negative Regulation of Degradation of Complement
UMLS_CUI
  • C1516745
Legacy_Concept_Name
  • Complement_Stabilization
FULL_SYN
  • Complement StabilizationSYNCI
  • Negative Regulation of Degradation of ComplementPTNCI
DEFINITION
  • Complement Stabilization inhibits conjugation, transport, oxidation, or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins. Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.NCI
code
  • C40684
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