About: Ancitabine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ancitabine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Ancitabine Hydrochloride
NSC_Code
  • 145668
UMLS_CUI
  • C0010557
CAS_Registry
  • 10212-25-6
FDA_UNII_Code
  • 3T6920M469
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39199
PDQ_Closed_Trial_Search_ID
  • 39199
Chemical_Formula
  • C9H11N3O4.ClH
Legacy_Concept_Name
  • Ancitabine_Hydrochloride
FULL_SYN
  • CycloCMP HydrochlorideSYNCI
  • Ancitabine HydrochloridePTNCI
  • Ancytabine HydrochlorideSYNCI
  • CyclocytidineSYNCI
  • Cyclocytidine hydrochlorideSYDTPNSC0145668
  • CyclocytidineSYDTPNSC0145668
  • 6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a beta,9a beta))SNNCI
  • CycloCMP hydrochlorideSYDTPNSC0145668
  • ANCITABINE HYDROCHLORIDEPTFDA3T6920M469
  • Cyclocytidine HydrochlorideSYNCI
  • AncidFBNCI
  • Cyclocytidine HCLSYNCI
  • Ancitabine hydrochlorideSYDTPNSC0145668
  • U-33, 624ACNNCI
DEFINITION
  • The hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.NCI
code
  • C403
is someValuesFrom of
is Has_Salt_Form of
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