About: T-Cell Antiapoptosis Pathway

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About: T-Cell Antiapoptosis Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	T-Cell Antiapoptosis Pathway
rdfs:subClassOf	Immune Response Regulation Pathway Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	T-Cell Antiapoptosis Pathway
UMLS_CUI	C1515123
BioCarta_ID	h_vipPathway
ALT_DEFINITION	Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB.BIOCARTA
Legacy_Concept_Name	T-Cell_Antiapoptosis_Pathway
FULL_SYN	T-Cell Antiapoptosis PathwayPTNCI Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cellsPTBIOCARTA
code	C39266
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