About: Trka Receptor Signaling Pathway

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About: Trka Receptor Signaling Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Trka Receptor Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Trka Receptor Signaling Pathway
UMLS_CUI	C1519656
BioCarta_ID	h_trkaPathway
ALT_DEFINITION	Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation.BIOCARTA
Legacy_Concept_Name	Trka_Receptor_Signaling_Pathway
FULL_SYN	Trka Receptor Signaling PathwayPTBIOCARTA Trka Receptor Signaling PathwayPTNCI
code	C39259
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