About: HIV Induced T Cell Apoptosis Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • HIV Induced T Cell Apoptosis Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • HIV Induced T Cell Apoptosis Pathway
UMLS_CUI
  • C1512303
BioCarta_ID
  • h_tcapoptosisPathway
ALT_DEFINITION
  • HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction.BIOCARTA
Legacy_Concept_Name
  • HIV_Induced_T_Cell_Apoptosis_Pathway
FULL_SYN
  • HIV Induced T Cell ApoptosisPTBIOCARTA
  • HIV Induced T Cell Apoptosis PathwayPTNCI
code
  • C39244
is someValuesFrom of
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