About: RNA Polymerase III Transcription Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	RNA Polymerase III Transcription Pathway
rdfs:subClassOf	Genetic Information Processing Pathway
Semantic_Type	Functional Concept
Preferred_Name	RNA Polymerase III Transcription Pathway
UMLS_CUI	C1514668
BioCarta_ID	h_RNApol3Pathway
ALT_DEFINITION	Unlike the RNA polymerase II that transcribes a large variety of genes that encode proteins, RNA polymerase III transcribes only a limited number of genes (i.e., 5S rRNA, tRNA, 7SL RNA, U6 snRNA, and a few other small stable RNAs); however, the transcriptional activities of RNA pol III along with pol I account for 80% of total RNA synthesis. The A and B block sequences found in most pol III promoters are recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsDNA and participation of TFIIIB. Unlike pol I and II, pol III termination occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of RNA and pol III transcription; however, deletion of La has no apparent effect on pol III activity.BIOCARTA
Legacy_Concept_Name	RNA_Polymerase_III_Transcription_Pathway
FULL_SYN	RNA polymerase III transcriptionPTBIOCARTA RNA Polymerase III Transcription PathwayPTNCI
code	C39225
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