About: RB Checkpoint Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	RB Checkpoint Signaling Pathway
rdfs:subClassOf	Signaling Pathway Cell Cycle Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	RB Checkpoint Signaling Pathway
UMLS_CUI	C1514642
BioCarta_ID	h_rbPathway
ALT_DEFINITION	Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when DNA is damaged. The ATM protein kinase detects DNA damage and, in response to this, activates DNA repair factors and inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response to DNA damage are the tumor suppressor p53 and the checkpoint kinase chk1. In turn, the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin dependent kinase 2) preventing passage from G1 to S phase and harmful replication of damaged DNA. One of the targets of cdk2 is the Rb gene product, another tumor suppressor. When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription of genes required for progression through the cell cycle. When phosphorylated by cell cycle dependent kinases like cdk2 and cdk4, Rb no longer interacts with E2F and the cell cycle proceeds through the G1-S checkpoint. DNA damage also regulates the G2-M phase transition by acting on the cell cycle regulator cdc2.BIOCARTA
Legacy_Concept_Name	RB_Checkpoint_Signaling_Pathway
FULL_SYN	RB Tumor Suppressor/Checkpoint Signaling in response to DNA damagePTBIOCARTA RB Checkpoint Signaling PathwayPTNCI
code	C39218
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