About: Rac1 Cell Motility Signaling Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Rac1 Cell Motility Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Rac1 Cell Motility Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Rac1 Cell Motility Signaling Pathway
UMLS_CUI	C1514677
BioCarta_ID	h_rac1Pathway
ALT_DEFINITION	Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal structure and other aspects of cell structure are involved in cell motility. Rac-1 is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors, including Trio and Vav. Sos-1 is involved in Ras signaling and also acts as a GEF for Rac to transduce signals between Ras and Rac. SWAP-70 is a Rac GEF that binds IP3 and transduces signals from tyrosine kinases to Rac to modulate the cytoskeleton and cause membrane ruffling. GAPs are GTPase- activating proteins. Rac stimulates the formation of actin-based structures such as filopodia and lamellipodia, while GAPs such as chimerin oppose the formation of these Rac dependent structures. Several different factors downstream of Rac act on cytoskeletal structure and other aspects of cell motility. Pak1 provides a direct link from Rac to cell motility through phosphorylation of the myosin light chain. Pak1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin as one target. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses its activity. In neurons, Rac acts through the protein kinase cdk5 and p35 to phosphorylate and down regulate Pak1, increasing neuronal migration. Rac-1 also interacts with several other factors to regulate a variety of processes. Interaction of Por1 with Rac-1 is involved in membrane ruffling. WAVE is a member of the WASP family of proteins that regulate actin organization and that is involved in Rac signaling to cause membrane ruffling. Interaction of Rac-1 with MEKK1 integrates Rac signaling with pathways signaling through map kinases.BIOCARTA
Legacy_Concept_Name	Rac1_Cell_Motility_Signaling_Pathway
FULL_SYN	Rac1 Cell Motility Signaling PathwayPTNCI Rac 1 cell motility signaling pathwayPTBIOCARTA
code	C39208
is someValuesFrom of	nodeID://b653936 nodeID://b653954 nodeID://b654181 nodeID://b654306 nodeID://b660913 nodeID://b662042 nodeID://b662072 nodeID://b685931 nodeID://b685952 nodeID://b688837 nodeID://b689684 nodeID://b691455 nodeID://b694545 nodeID://b694638 nodeID://b698700 nodeID://b699011 nodeID://b699376 nodeID://b699488 nodeID://b702850 nodeID://b703002 nodeID://b703436 nodeID://b706167 nodeID://b706399 nodeID://b707434 nodeID://b707529 nodeID://b718585 nodeID://b721055 nodeID://b722397 nodeID://b726258

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 49 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software