About: Ptc1 Regulation of Cell Cycle Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Ptc1 Regulation of Cell Cycle Pathway
rdfs:subClassOf	Cell Cycle Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Ptc1 Regulation of Cell Cycle Pathway
UMLS_CUI	C1514596
BioCarta_ID	h_ptc1Pathway
ALT_DEFINITION	Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic signal in the developing CNS, organizing the spatial patterning of cells in the midbrain and inducing proliferation of neuronal precursor cells in the developing cerebellum, neural tube, and retina. Proliferative signaling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas. Sonic hedgehog signaling may proceed by more than one mechanism. One signaling pathway is activated by Shh binding to Patched (Ptc-1) which releases inhibition of the GPCR Smoothened, activating the Shh signaling pathway and allowing progression through the G1 phase of the cell cycle. Shh can also affect progression through the G2/M transition. Patched binds to phosphorylated Cyclin B1, one component of the M-phase promoting factor (MPF), along with the kinase Cdc2. The interaction of Cyclin B1 with Patched blocks MPF activity, blocking progression through the G2/M transition. Shh binding leads to degradation of Ptc-1, release of Cyclin B1, and entry of the cyclin B1 into the nucleus. Patched acts as a tumor suppressor by blocking MPF activity. Blockade of the Hedgehog pathway by cyclopamine demonstrated the therapeutic potential of Hedgehog inhibition in the treatment of some cancers.BIOCARTA
Legacy_Concept_Name	Ptc1_Regulation_of_Cell_Cycle_Pathway
FULL_SYN	Ptc1 Regulation of Cell Cycle PathwayPTNCI Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cyclePTBIOCARTA
code	C39203
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