About: PDGF Signaling Pathway

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	PDGF Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	PDGF Signaling Pathway
UMLS_CUI	C1518784
BioCarta_ID	h_pdgfPathway
ALT_DEFINITION	Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combination of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins.BIOCARTA
Legacy_Concept_Name	PDGF_Signaling_Pathway
FULL_SYN	PDGF Signaling PathwayPTNCI PDGF Signaling PathwayPTBIOCARTA
code	C39184
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