About: p38 MAPK Signaling Pathway BioCarta

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Attributes	Values
rdf:type	Class
rdfs:label	p38 MAPK Signaling Pathway BioCarta
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	p38 MAPK Signaling Pathway BioCarta
UMLS_CUI	C1515678
BioCarta_ID	h_p38mapkPathway
ALT_DEFINITION	p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1.BIOCARTA
Legacy_Concept_Name	p38_MAPK_Signaling_Pathway
FULL_SYN	p38 MAPK Signaling Pathway BioCartaPTNCI p38 MAPK Signaling PathwayPTBIOCARTA
code	C39178
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