About: Myosin Phosphatase Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Myosin Phosphatase Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Myosin Phosphatase Pathway
UMLS_CUI
  • C1513801
BioCarta_ID
  • h_myosinPathway
ALT_DEFINITION
  • The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation, and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation, and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction.BIOCARTA
Legacy_Concept_Name
  • Myosin_Phosphatase_Pathway
FULL_SYN
  • PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatasePTBIOCARTA
  • Myosin PathwaySYNCI
  • Myosin Phosphatase PathwayPTNCI
code
  • C39160
is someValuesFrom of
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