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AttributesValues
rdf:type
rdfs:label
  • Antigen Presentation Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Antigen Presentation Pathway
UMLS_CUI
  • C1516014
BioCarta_ID
  • h_mhcPathway
ALT_DEFINITION
  • Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules.BIOCARTA
Legacy_Concept_Name
  • Antigen_Presentation_Pathway
FULL_SYN
  • Antigen Presentation PathwayPTNCI
  • Antigen Processing and PresentationPTBIOCARTA
code
  • C39153
is someValuesFrom of
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