About: Intrinsic Prothrombin Activation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Intrinsic Prothrombin Activation Pathway
rdfs:subClassOf	Protein Activation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Intrinsic Prothrombin Activation Pathway
UMLS_CUI	C1517573
BioCarta_ID	h_intrinsicPathway
ALT_DEFINITION	Blood coagulation or clotting takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The intrinsic mechanism of prothrombin activator formation begins with trauma to the blood or exposure of blood to collagen in a traumatized vessel wall. This usually also results in damage to fragile platelets. The formation of a clot by this mechanism usually takes 1 to 6 minutes. This cascade begins with the activation of factor XII and the release of platelet factor 3 (PF3) from damaged platelets. Activated factor XII cleaves and actives factor XI and prekallikrein (PK). Factor XII is also activated by activated prekallikrein (aPK) in an internal amplification loop. Calcium (Ca++) is required for the initial three steps. The prothrombin activator in the intrinsic pathway is very similar to the activator in the extrinsic pathway. Antithrombin III inhibits the activity of thrombin and also two of the steps in the formation of the activator. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation.BIOCARTA
Legacy_Concept_Name	Intrinsic_Prothrombin_Activation_Pathway
FULL_SYN	Intrinsic Prothrombin Activation PathwayPTBIOCARTA Intrinsic Prothrombin Activation PathwayPTNCI
code	C39132
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