About: Skeletal Muscle Hypertrophy Pathway

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About: Skeletal Muscle Hypertrophy Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Skeletal Muscle Hypertrophy Pathway
rdfs:subClassOf	Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Skeletal Muscle Hypertrophy Pathway
UMLS_CUI	C1519338
BioCarta_ID	h_igf1mtorpathway
ALT_DEFINITION	Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size of existing muscle fibers. One signaling pathway involved in regulating skeletal muscle atrophy and hypertrophy is the AKT/mTOR pathway. The mTOR pathway activity increases in response to muscle activity during hypertrophy and decreases in activity during atrophy. Blocking this pathway genetically or with the mTOR inhibitor rapamycin blocks hypertrophy and genetic activation of the pathway induces hypertrophy. One agent that promotes muscle hypertrophy is the growth factor IGF-1. IGF-1 activates AKT, GSK-3 beta, and mTOR to promote hypertrophy. In contrast, the calcineurin pathway is not involved in hypertrophy and is down-regulated by agents such as IGF-1 that promote hypertrophy. Calcineurin may modulate other aspects of muscle function such as the development of slow muscle fibers through transcriptional regulation. These pathways lead to regulation of protein translation, with increased translation apparently acting as a key regulatory point in skeletal muscle hypertrophy. Agents such as IGF-1 that stimulate skeletal muscle hypertrophy may provide treatments for muscle atrophy and wasting.BIOCARTA
Legacy_Concept_Name	Skeletal_Muscle_Hypertrophy_Pathway
FULL_SYN	Skeletal Muscle Hypertrophy PathwayPTNCI Skeletal muscle hypertrophy is regulated via AKT/mTOR pathwayPTBIOCARTA
code	C39113
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