About: Granulocyte Adhesion Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Granulocyte Adhesion Pathway
rdfs:subClassOf	Cell Motility Pathway
Semantic_Type	Functional Concept
Preferred_Name	Granulocyte Adhesion Pathway
UMLS_CUI	C1512270
BioCarta_ID	h_granulocytesPathway
ALT_DEFINITION	Cell adhesion is a fundamental feature of multicellular organisms including their defense mechanisms. In the later case in mammals, leukocytes play central role. They bind bacteria, parasites, viruses, tumor cells etc. Furthermore, their interactions with the endothelium are of special importance. During an inflammation or immune reaction, specialized leukocytes (eosinophilic granulocytes) adhere to and pass through the endothelium of the blood vessels and the underlying matrix. The reaction passes through the following steps: 1. Rolling (the flow of cells is slowed down by first making contacts to the endothelium via P-, E-, and L-selectins and their receptors); 2. Adhesion (After activation of leukocyte integrins, firm contacts are established between them and endothelium molecules of the Ig superfamily - LFA-1, Mac-1, VLA-4 etc.); 3. Flattening of the cells and diapedesis (Adhering leukocytes crawl to an intercellular junction of the endothelium and then transmigrate to or even through the intercellular matrix. This is mediated by homophilic interactions of PECAM and CD31.BIOCARTA
Legacy_Concept_Name	Granulocyte_Adhesion_Pathway
FULL_SYN	Adhesion and Diapedesis of GranulocytesPTBIOCARTA Granulocyte Adhesion PathwayPTNCI
code	C39097
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