About: Erythrocyte Differentiation Pathway

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About: Erythrocyte Differentiation Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Erythrocyte Differentiation Pathway
rdfs:subClassOf	Cell Differentiation or Development Pathway
Semantic_Type	Functional Concept
Preferred_Name	Erythrocyte Differentiation Pathway
UMLS_CUI	C1516959
BioCarta_ID	h_erythPathway
ALT_DEFINITION	Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias.BIOCARTA
Legacy_Concept_Name	Erythrocyte_Differentiation_Pathway
FULL_SYN	Erythrocyte Differentiation PathwayPTNCI Erythrocyte Differentiation PathwayPTBIOCARTA
code	C39073
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