About: eIF4 Regulation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	eIF4 Regulation Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	eIF4 Regulation Pathway
UMLS_CUI	C1515620
BioCarta_ID	h_eif4Pathway
ALT_DEFINITION	eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis.BIOCARTA
Legacy_Concept_Name	eIF4_Regulation_Pathway
FULL_SYN	eIF4 Regulation PathwayPTNCI Regulation of eIF4e and p70 S6 KinaseSYBIOCARTA Regulation of eif-4e and p70s6 KinasePTBIOCARTA
code	C39062
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