About: eIF2 Regulation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	eIF2 Regulation Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	eIF2 Regulation Pathway
UMLS_CUI	C1515619
BioCarta_ID	h_eif2Pathway
ALT_DEFINITION	Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis.BIOCARTA
Legacy_Concept_Name	eIF2_Regulation_Pathway
FULL_SYN	Regulation of eIF2PTBIOCARTA eIF2 Regulation PathwayPTNCI
code	C39061
is someValuesFrom of	nodeID://b642227 nodeID://b645383 nodeID://b668661 nodeID://b668667 nodeID://b668685 nodeID://b668693 nodeID://b668765 nodeID://b671288 nodeID://b671297 nodeID://b671354 nodeID://b683287 nodeID://b700857 nodeID://b720866

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