About: Map Kinase Inactivation of SMRT Corepressor Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Map Kinase Inactivation of SMRT Corepressor Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	Map Kinase Inactivation of SMRT Corepressor Pathway
UMLS_CUI	C1512988
BioCarta_ID	h_egfr_smrtePathway
ALT_DEFINITION	Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EGF receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF.BIOCARTA
Legacy_Concept_Name	Map_Kinase_Inactivation_of_SMRT_Corepressor_Pathway
FULL_SYN	Map Kinase Inactivation of SMRT CorepressorPTBIOCARTA Map Kinase Inactivation of SMRT Corepressor PathwayPTNCI
DEFINITION	Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF.NCI
code	C39059
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