About: EGF Signaling Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: EGF Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	EGF Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	EGF Signaling Pathway
UMLS_CUI	C1512120
BioCarta_ID	h_egfPathway
ALT_DEFINITION	The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor. Inhibitors of the EGF receptor are being pursued as potential cancer therapies and EGF may stimulate wound healing. Mutation of the EGF receptor has been associated with cancer in humans. The proliferative effects of EGF are signaled through several pathways. Binding of EGF results in EGF receptor dimerization, autophosphorylation of the receptor, and tyrosine phosphorylation of other proteins. The EGF receptor activates ras and the MAP kinase pathway, ultimately causing phosphorylation of transcription factors such as c-Fos to create AP-1 and ELK-1 that contribute to proliferation. Activation of STAT-1 and STAT-3 transcription factors by JAK kinases in response to EGF contributes to proliferative signaling. Phosphatidylinositol signaling and calcium release induced by EGF activate protein kinase C, another component of EGF signaling. Crosstalk of EGF signaling with other pathways make the EGF receptor a junction point between signaling systems.BIOCARTA
Legacy_Concept_Name	EGF_Signaling_Pathway
FULL_SYN	EGF Signaling PathwayPTBIOCARTA EGF Signaling PathwayPTNCI
code	C39058
is someValuesFrom of	nodeID://b655213 nodeID://b657780 nodeID://b667775 nodeID://b668562 nodeID://b668620 nodeID://b668794 nodeID://b668838 nodeID://b670430 nodeID://b670466 nodeID://b672580 nodeID://b672650 nodeID://b675626 nodeID://b677675 nodeID://b678883 nodeID://b684485 nodeID://b684646 nodeID://b684738 nodeID://b684816 nodeID://b688300 nodeID://b688439 nodeID://b688565 nodeID://b688651 nodeID://b688726 nodeID://b688819 nodeID://b689157 nodeID://b689283 nodeID://b689666 nodeID://b699417 nodeID://b699861 nodeID://b700703 nodeID://b702779 nodeID://b705176 nodeID://b706289 nodeID://b706340 nodeID://b706529 nodeID://b707609 nodeID://b710014 nodeID://b710104 nodeID://b711125 nodeID://b711167 nodeID://b711217 nodeID://b712417 nodeID://b712466 nodeID://b712521 nodeID://b724383 nodeID://b726295

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software