About: Apoptotic DNA Fragmentation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Apoptotic DNA Fragmentation Pathway
rdfs:subClassOf	Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Apoptotic DNA Fragmentation Pathway
UMLS_CUI	C1516045
BioCarta_ID	h_DNAfragmentPathway
ALT_DEFINITION	Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria. A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic signaling pathways. One nuclease involved in apoptosis is DNA fragmentation factor (DFF), a caspase-activated DNAse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic signaling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic signaling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF.BIOCARTA
Legacy_Concept_Name	Apoptotic_DNA_Fragmentation_Pathway
FULL_SYN	Apoptotic DNA Fragmentation PathwayPTNCI Apoptotic DNA fragmentation and tissue homeostasisPTBIOCARTA
code	C39051
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