About: Cyclin Regulation of Cell Cycle Pathway

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About: Cyclin Regulation of Cell Cycle Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Cyclin Regulation of Cell Cycle Pathway
rdfs:subClassOf	Cell Cycle Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Cyclin Regulation of Cell Cycle Pathway
UMLS_CUI	C1511582
BioCarta_ID	h_cellcyclePathway
ALT_DEFINITION	The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed.BIOCARTA
Legacy_Concept_Name	Cyclin_Regulation_of_Cell_Cycle_Pathway
FULL_SYN	Cyclins and Cell Cycle RegulationPTBIOCARTA Cyclin Regulation of Cell Cycle PathwayPTNCI
code	C39025
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