About: CD40L Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	CD40L Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	CD40L Signaling Pathway
UMLS_CUI	C1511423
BioCarta_ID	h_cd40Pathway
ALT_DEFINITION	The CD40 receptor was first associated with expression in B cells and the role it plays through its ligand CD40L (CD154) in moderating T cell activation. Broader expression may indicate a broader role for CD40 and CD40L in immune function and disease states such as transplant rejection and HIV infection. Disruption and modulation of CD40 interaction with CD40L may prove therapeutic in the treatment of autoimmune disorders, heart disease, and cancer. As a member of the TNF receptor family, CD40 relies on interaction with TRAF proteins to mediate an intracellular signal in response to CD40L binding. The pathway downstream of TRAFs activates the transcription factor NF-kappaB through a kinase pathway involving map kinases, NIK (NF-kappaB inducing kinase) and I-kappa B kinases. Some CD40 responses like regulation of immunoglobulin expression might be mediated by NF-kappaB transcriptional activation.BIOCARTA
Legacy_Concept_Name	CD40L_Signaling_Pathway
FULL_SYN	CD40L Signaling PathwayPTNCI CD40L Signaling PathwayPTBIOCARTA
code	C39019
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