About: CCR3 Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	CCR3 Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	CCR3 Signaling Pathway
UMLS_CUI	C1511415
BioCarta_ID	h_CCR3Pathway
ALT_DEFINITION	Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho is a G protein that activates ROCK, a protein kinase. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation, and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage.BIOCARTA
Legacy_Concept_Name	CCR3_Signaling_Pathway
FULL_SYN	CCR3 Signaling PathwayPTNCI CCR3 signaling in EosinophilsPTBIOCARTA
code	C39017
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