About: Caspase Cascade Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Caspase Cascade Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Caspase Cascade Pathway
rdfs:subClassOf	Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Caspase Cascade Pathway
UMLS_CUI	C1516311
BioCarta_ID	h_caspasePathway
ALT_DEFINITION	Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. Caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. The caspases at the upper end of the cascade include caspase-8 and caspase-9. Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS. The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria, which then interacts with Apaf-1, causing self-cleavage and activation of caspase-9. Caspase-3, -6, and -7 are downstream caspases that are activated by the upstream proteases and act themselves to cleave cellular targets. Granzyme B and perforin proteins released by cytotoxic T cells induce apoptosis in target cells, forming transmembrane pores, and triggering apoptosis, perhaps through cleavage of caspases, although caspase-independent mechanisms of Granzyme B mediated apoptosis have been suggested.BIOCARTA
Legacy_Concept_Name	Caspase_Cascade_Pathway
FULL_SYN	Caspase Cascade in ApoptosisPTBIOCARTA Caspase Cascade PathwayPTNCI
code	C39014
is someValuesFrom of	nodeID://b642813 nodeID://b646481 nodeID://b648768 nodeID://b648779 nodeID://b648788 nodeID://b649551 nodeID://b649560 nodeID://b649574 nodeID://b652412 nodeID://b652427 nodeID://b652441 nodeID://b652459 nodeID://b652491 nodeID://b652506 nodeID://b652527 nodeID://b652556 nodeID://b652589 nodeID://b657822 nodeID://b657838 nodeID://b657856 nodeID://b657873 nodeID://b657913 nodeID://b657931 nodeID://b657952 nodeID://b657967 nodeID://b658000 nodeID://b675924 nodeID://b677551 nodeID://b686066 nodeID://b686313 nodeID://b700463 nodeID://b702322 nodeID://b710957 nodeID://b716009

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 89 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software