About: Serine/Threonine-Protein Kinase mTOR     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Serine/Threonine-Protein Kinase mTOR
equivalentClass
OMIM_Number
  • 601231
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Serine/Threonine-Protein Kinase mTOR
UMLS_CUI
  • C1307407
ALT_DEFINITION
  • A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target of rapamycin may be more active in some types of cancer cells than it is in normal cells. Blocking mammalian target of rapamycin may cause the cancer cells to die. It is a type of serine/threonine protein kinase.NCI-GLOSS
Legacy_Concept_Name
  • FKBP12-Rapamycin_Complex_Associated_Protein-1
FULL_SYN
  • EC 2.7.11.1SYNCI
  • FKBP12-Rapamycin Complex-Associated ProteinSYNCI
  • FKBP-Rapamycin Associated ProteinSYNCI
  • FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1SYNCI
  • Rapamycin Target ProteinSYNCI
  • FKBP12 Rapamycin Complex Associated Protein 1SYNCI
  • FK506 Binding Protein 12-Rapamycin Associated Protein 1SYNCI
  • FK506 Binding Protein 12-Rapamycin Associated Protein 2SYNCI
  • Serine/Threonine-Protein Kinase mTORPTNCI
  • Rapamycin Target Protein 1SYNCI
  • FRAPSYNCI
  • mTORSYNCI
  • FRAP1SYNCI
  • FRAP2SYNCI
  • RAFT1SYNCI
  • RAPT1SYNCI
  • Mammalian Target of RapamycinSYNCI
  • mammalian target of rapamycinPTNCI-GLOSSCDR0000653127
  • Mechanistic Target of RapamycinSYNCI
Swiss_Prot
  • P42345
DEFINITION
  • Serine/threonine-protein kinase mTOR (2549 aa, ~289 kDa) is encoded by the human MTOR gene. This protein is involved in protein phosphorylation, signaling and cell growth.NCI
DesignNote
  • FKBP12-Rapamycin Complex Associated Protein 1 contains 8 HEAT repeats and is a target for the G1 cell-cycle arrest and immunosuppressive effects of FKBP12-rapamycin complex. mTOR regulates ribosome biogenesis and cell growth in response to ATP or nutrient concentrations. FRAP phosphorylation of p53 (inhibited by rapamycin) downregulates PP2A, activates BAX, and induces mitochondrial membrane permeability and caspase activation. Mitogen-induced phospholipase D-dependent phosphatidic acid interacts with the mTOR rapamycin target domain. Cellular stress inhibits MTOR activity by stabilizing MTOR-RAPTOR binding, which also promotes MTOR phosphorylation of 4EBP1 and enhances MTOR activity toward S6K1. MTOR binds UBQLN1.
code
  • C38929
is someValuesFrom of
is Has_Target of
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