About: B-Lymphocyte Antigen CD20     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • B-Lymphocyte Antigen CD20
equivalentClass
OMIM_Number
  • 112210
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • B-Lymphocyte Antigen CD20
UMLS_CUI
  • C0054946
Legacy_Concept_Name
  • CD20_Antigen
FULL_SYN
  • CD20 AntigenSYNCI
  • CD20 ReceptorSYNCI
  • B-Lymphocyte Antigen CD20PTNCI
  • B1SYNCI
  • Bp35SYNCI
  • MS4A1SYNCI
  • Membrane-Spanning 4-Domains Subfamily A Member 1SYNCI
  • Leu-16SYNCI
  • B-Lymphocyte Surface Antigen B1SYNCI
  • B-Lymphocyte Antigen CD20SYNCITCGA
Swiss_Prot
  • P11836
DEFINITION
  • B-lymphocyte antigen CD20 (297 aa, ~33 kDa) is encoded by the human MS4A1 gene. This protein plays a role in both the activation and proliferation of B-cells.NCI
DesignNote
  • Expressed during B-cell ontogeny (early pre-B-cell to plasma cell) by human CD20 Gene (MS4A Family), 297-aa 33-kDa CD20 Antigen is a phosphorylated cell surface integral membrane protein shown to participate in B-cell proliferation, development, and differentiation into plasma cells. MS4A family proteins share structural similarity, sequence homology, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. CD20 may be involved in regulation of B-cell activation and may be regulated by protein kinases.
code
  • C38896
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