About: Ubiquitin-mediated Proteolysis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Ubiquitin-mediated Proteolysis Pathway
rdfs:subClassOf	Degradation Pathway Genetic Information Processing Pathway
Semantic_Type	Functional Concept
Preferred_Name	Ubiquitin-mediated Proteolysis Pathway
UMLS_CUI	C1519749
KEGG_ID	hsa04120
ALT_DEFINITION	Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.KEGG
Legacy_Concept_Name	Ubiquitin-mediated_Proteolysis_Pathway
FULL_SYN	Ubiquitin-mediated Proteolysis PathwayPTNCI Ubiquitin-mediated ProteolysisPTKEGG
code	C38881
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