About: Steroid Hormone Biosynthesis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Steroid Hormone Biosynthesis Pathway
rdfs:subClassOf	Lipid Metabolism Pathway
Semantic_Type	Functional Concept
Preferred_Name	Steroid Hormone Biosynthesis Pathway
UMLS_CUI	C0597517
KEGG_ID	hsa00140
ALT_DEFINITION	Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland.KEGG
Legacy_Concept_Name	C21-Steroid_Hormone_Metabolism_Pathway
FULL_SYN	Androgen and Estrogen MetabolismSYKEGG Steroid Hormone Biosynthesis PathwayPTNCI Steroid Hormone BiosynthesisPTKEGG C21-Steroid Hormone MetabolismSYKEGG
DesignNote	KEGG merged hsa00150 with hsa00140.
code	C38800
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