About: 3-AP/Fludarabine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 3-AP/Fludarabine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 3-AP/Fludarabine
UMLS_CUI
  • C1328164
In_Clinical_Trial_For
  • Acute or chronic leukemia; myelodysplastic syndrome
Legacy_Concept_Name
  • _3-AP_Fludarabine
FULL_SYN
  • 3-AP/FludarabinePTNCI
  • 3AP/FAMPABNCI
DEFINITION
  • A combination of the thiosemicarbazone 3-aminopyridine-2-carboxaldehyde (3-AP) and the nucleoside analogue fludarabine with antineoplastic activity. The agents in 3-AP/fludarabine, act synergistically to inhibit the enzyme ribonucleotide reductase.. Composed of two subunits, this enzyme catalyzes the rate-limiting step in the conversion of ribonucleotides to deoxyribonucleotides. The 3-AP binds to and inactivates one subunit while fludarabine binds to and inactivates the other. Fludarabine also inhibits DNA polymerase alpha and DNA primase. At low concentrations, this agent arrests tumor cells in the S-phase of the cell cycle; at higher concentrations, in the G0/G1 phase of the cell cycle. (NCI04)NCI
code
  • C38719
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