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AttributesValues
rdf:type
rdfs:label
  • Paricalcitol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Paricalcitol
UMLS_CUI
  • C0724464
CAS_Registry
  • 131918-61-1
Accepted_Therapeutic_Use_For
  • Secondary hyperparathyroidism, prevention and treatment
FDA_UNII_Code
  • 6702D36OG5
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 315740
PDQ_Closed_Trial_Search_ID
  • 315740
Chemical_Formula
  • C27H44O3
Legacy_Concept_Name
  • Paricalcitol
CHEBI_ID
  • CHEBI:7931
FULL_SYN
  • ParicalcitolPTNCI
  • Compound 49510SYNCI
  • paricalcitolPTNCI-GLOSSCDR0000340933
  • ZemplarBRNCI
  • (7e,22e)-19-Nor-9,10-Secoergosta-5,7,22-Triene-1.Alpha.,3.Beta.,25-TriolSNNCI
  • PARICALCITOLPTFDA6702D36OG5
DEFINITION
  • A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)NCI
code
  • C38693
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