About: Phentolamine Mesylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Phentolamine Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Phentolamine Mesylate
UMLS_CUI
  • C0733398
CAS_Registry
  • 65-28-1
Accepted_Therapeutic_Use_For
  • Dermal necrosis; Hypertensive-associated episodes with pheochromocytoma, prevention or control
In_Clinical_Trial_For
  • Erectile dysfunction, therapy-induced
FDA_UNII_Code
  • Y7543E5K9T
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 360460
PDQ_Closed_Trial_Search_ID
  • 360460
Chemical_Formula
  • C17H19N3O.CH4O3S
Legacy_Concept_Name
  • Phentolamine
FULL_SYN
  • 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline MonomethanesulfonateSNNCI
  • PHENTOLAMINE MESYLATEPTFDAY7543E5K9T
  • RegitineBRNCI
  • Phentolamine MesylatePTNCI
DEFINITION
  • The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.NCI
code
  • C38691
is Has_Salt_Form of
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