About: Elongation Factor 1A2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Elongation Factor 1A2
equivalentClass
OMIM_Number
  • 602959
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Elongation Factor 1A2
UMLS_CUI
  • C1531428
Legacy_Concept_Name
  • Elongation_Factor-1A2
FULL_SYN
  • EF-1-Alpha-2SYNCI
  • Elongation Factor-1 AlphaSYNCI
  • Elongation Factor 1-Alpha 2SYNCI
  • EEF1A2SYNCI
  • eEF1A-2SYNCI
  • Eukaryotic Translation Elongation Factor 1 Alpha 2SYNCI
  • Statin S1SYNCI
  • Elongation Factor 1A2PTNCI
Swiss_Prot
  • Q05639
DEFINITION
  • Expressed in terminally differentiated brain, heart, and skeletal muscle cells by human EEF1A2 Gene (EF-Tu/EF-1A Family), 463-aa 50-kDa Elongation Factor 1A2 is an alpha subunit of elongation factor-1 (EEF1) complex responsible for enzymatic delivery and GTP-dependent binding of aminoacyl tRNAs to the A-site of ribosomes during protein biosynthesis. EEF1A gene coding regions are highly similar; EEF1A2 exhibits 92% amino acid identity to EEF1A1. EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth, and decreases fibroblast doubling time. EEF1A2 may be critical in development of ovarian cancer. (NCI)NCI
code
  • C38583
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