About: CREB Family Gene

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Attributes	Values
rdf:type	Class
rdfs:label	CREB Family Gene
rdfs:subClassOf	Transcription Factor Gene nodeID://b654865 nodeID://b654866
Semantic_Type	Gene or Genome
Preferred_Name	CREB Family Gene
UMLS_CUI	C1511455
Legacy_Concept_Name	CREB_Family_Gene
FULL_SYN	CREB Family GenePTNCI
Gene_Encodes_Product	cAMP Responsive Element Binding Protein
DEFINITION	Ubiquitously or widely expressed human CREB Family Genes (bZIP/CREB Family) encode conserved cAMP Responsive Element Binding Proteins, nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)NCI
code	C38534
is rdfs:subClassOf of	ATF5 Gene ATF3 Gene CREBL2 Gene ATF2 Gene CREB1 Gene CREB3 Gene CREB3L4 Gene CREB5 Gene ATF1 Gene CREB3L1 Gene CREB3L2 Gene CREB3L3 Gene
is someValuesFrom of	nodeID://b725766

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