About: Transferrin Receptor 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Transferrin Receptor 1
equivalentClass
OMIM_Number
  • 190010
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Transferrin Receptor 1
UMLS_CUI
  • C1619635
Legacy_Concept_Name
  • Transferrin_Receptor-1
FULL_SYN
  • TRSYNCI
  • Transferrin Receptor 1PTNCI
  • CD71 AntigenSYNCI
  • T9SYNCI
  • p90SYNCI
  • TFRSYNCI
  • CD71SYNCI
  • TFR1SYNCI
  • TFRCSYNCI
  • TRFRSYNCI
  • Transferrin Receptor Protein 1SYNCI
  • Transferrin ReceptorSYNCI
Swiss_Prot
  • P02786
DEFINITION
  • Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a glycosylated, phosphorylated, and palmitoylated type II membrane disulfide-linked homodimeric glycoprotein involved in cellular uptake of iron via receptor-mediated endocytosis. After intracellular iron release, apotransferrin-receptor is recycled to the cell surface with release of apotransferrin. Transferrin receptor appears necessary for nervous system and erythrocyte development, binds HLA class II histocompatibility antigen DR1, and binds parvoviruses that enter and infect cells. Ligand HFE competes with transferrin for binding to an overlapping C-terminal site. Proteolytic cleavage at Arg100 produces the glycosylated secreted sTfR isoform; used in a diagnostic test for anemia. (NCI)NCI
code
  • C38519
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