About: Upstream Stimulatory Factor 1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Upstream Stimulatory Factor 1
equivalentClass
OMIM_Number
  • 191523
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Upstream Stimulatory Factor 1
UMLS_CUI
  • C1451716
Legacy_Concept_Name
  • Upstream_Stimulatory_Factor_1
FULL_SYN
  • USF1SYNCI
  • Major Late Transcription Factor 1SYNCI
  • Upstream Stimulatory Factor 1PTNCI
Swiss_Prot
  • P22415
DEFINITION
  • Ubiquitously expressed by human USF1 Gene, 310-aa 34-kDa nuclear Upstream Stimulatory Factor 1 is a bHLH transcription factor that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein and USF1 can act synergistically with GTF2I to activate transcription. Direct GTF2I interaction requires the USF1 activation and dimerization domains. USF1/USF2A heterodimer represents most USF binding activity. (NCI)NCI
code
  • C38368
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