About: ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte
rdfs:subClassOf
Has_Target
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte
NSC_Code
  • 729233
UMLS_CUI
  • C1512138
Legacy_Concept_Name
  • ESO-1_Reactive_Autologous_Tumor_Infiltrating_Lymphocyte
FULL_SYN
  • ESO-1 Reactive Autologous Tumor Infiltrating LymphocytePTNCI
DEFINITION
  • Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes which may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)NCI
code
  • C38120
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