About: SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte
rdfs:subClassOf
Has_Target
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte
NSC_Code
  • 722760
UMLS_CUI
  • C1519129
Legacy_Concept_Name
  • SBIL-2_Transduced_Autologous_Tumor-Infiltrating_Lymphocyte
FULL_SYN
  • SBIL-2 Transduced Autologous Tumor-Infiltrating LymphocytePTNCI
DEFINITION
  • A population of tumor-infiltrating lymphocytes (TILs) harvested from a patient and transduced with a retroviral vector encoding the gene for interleukin-2 (IL-2). TILs require IL-2 to sustain them when they are transferred back to the patient. By inserting the IL-2 gene into TILs in vitro so that TILs express IL-2 continuously it is possible to provide TIL-sustaining IL-2 in vivo specifically at the site of lymphocyte infiltration, thereby avoiding the toxicity associated with the systemic administration of IL-2. (NCI04)NCI
code
  • C38118
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