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AttributesValues
rdf:type
rdfs:label
  • Cisplatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Cisplatin
NSC_Code
  • 119875
UMLS_CUI
  • C0008838
CAS_Registry
  • 15663-27-1
Accepted_Therapeutic_Use_For
  • metastatic testicular cancer; ovarian cancer; head and neck cancer; breast cancer; Hodgkin's and non-Hodgkin's lymphoma; myeloma and melanoma
In_Clinical_Trial_For
  • Melanoma; Non-Hodgkin's Lymphoma; Pancreatic cancer; Renal cell cancer; Unspecified solid tumor; Salivary Gland Cancer; Testicular cancer; Thyroid cancer; Transitional cell cancer of the renal pelvis and ureter; Urethral cancer; Vulvar cancer
  • Anal cancer; Bladder cancer; Cervical cancer; Endometrial cancer; Esophageal cancer; Fallopian Tube cancer; Gastric cancer; Germ cell tumors; Head and Neck cancer; Localized malignant mesothelioma; Lung cancer small cell; Lung neoplasms
FDA_UNII_Code
  • Q20Q21Q62J
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39515
PDQ_Closed_Trial_Search_ID
  • 39515
Chemical_Formula
  • 2Cl.Pt.2H3N
Legacy_Concept_Name
  • Cisplatin
CHEBI_ID
  • CHEBI:27899
FULL_SYN
  • Cis-platinous Diamine DichlorideSYNCI
  • (SP-4-2)-DiamminedichloroplatinumSNNCI
  • Platinol-AQBRNCI
  • LederplatinFBNCI
  • CitoplatinoFBNCI
  • CisplatinumSYNCI
  • CisplatinPTDCP00524
  • Platinol- AQFBNCI
  • PlatiblastinSYDTPNSC0119875
  • Cis-platinumSYNCI
  • PlatiblastinFBNCI
  • Cis-platinum II Diamine DichlorideSYNCI
  • Cis-diamminedichloro Platinum (II)SYNCI
  • Peyrone's SaltSYNCI
  • Platiblastin-SFBNCI
  • DDPABNCI
  • Cis-platinum IISYNCI
  • CDDPABNCI
  • Platinum, Diaminedichloro-, cis- (8CI)SNNCI
  • Platinum DiamminodichlorideSYNCI
  • PlatinolSYDTPNSC0119875
  • CISPLATINPTFDAQ20Q21Q62J
  • PlacisFBNCI
  • Cis-diamminedichloroplatinumSYNCI
  • Peyrone's ChlorideSYNCI
  • CitosinFBNCI
  • Cis-diammine-dichloroplatinumSYNCI
  • PlatiranFBNCI
  • PlatinexFBNCI
  • PlatinolBRNCI
  • PlatosinFBNCI
  • PlatinumSYNCI
  • Platinol-AQ VHA PlusFBNCI
  • Cis-diamminedichloridoplatinumSYNCI
  • AbiplatinFBNCI
  • PlatamineFBNCI
  • BlastolemFBNCI
  • BriplatinFBNCI
  • CismaplatSYNCI
  • NeoplatinFBNCI
  • CisplatinPTNCI
  • CisplatylFBNCI
  • PlatistinFBNCI
  • cisplatinPTNCI-GLOSSCDR0000045230
  • CisplatinSYNCITCGA
  • Cis-dichloroammine Platinum (II)SYNCI
  • MetaplatinFBNCI
  • CisplatinaSYNCI
  • PlatinoxanSYNCI
  • PlastistilFBNCI
  • CysplatynaSYNCI
DEFINITION
  • An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.NCI
code
  • C376
is someValuesFrom of
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