About: Ixabepilone

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ixabepilone
rdfs:subClassOf	Epothilone B Analogue nodeID://b684461 nodeID://b684462 nodeID://b684463 nodeID://b684464 nodeID://b684465
Has_Target	Tubulin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Ixabepilone
NSC_Code	710428
UMLS_CUI	C1135132
CAS_Registry	219989-84-1
Accepted_Therapeutic_Use_For	metastatic or locally advanced breast cancer.
In_Clinical_Trial_For	Breast cancer; Endometrial cancer; Germ cell tumors; Head and Neck cancer; Leukemia; Lymphoma; Prostate cancer; Recurrent glioma; Small intestine cancer; Urinary tract cancer; Unspecified solid tumors
FDA_UNII_Code	K27005NP0A
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID	37860
PDQ_Closed_Trial_Search_ID	37860
Chemical_Formula	C27H42N2O5S
Legacy_Concept_Name	Ixabepilone
CHEBI_ID	CHEBI:63605
FULL_SYN	Epothilone-B BMS 247550SYNCI BMS247550CNNCI BMS-247550CNNCI IxabepilonePTNCI ixabepilonePTNCI-GLOSSCDR0000367463 (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dionePTDCP50584 Azaepothilone BSYNCI IxempraPTNCI-GLOSSCDR0000574038 IxempraBRNCI IXABEPILONEPTFDAK27005NP0A BMS-247550PTNCI-GLOSSCDR0000044891 BMS 247550CNNCI (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dioneSNNCI EpothiloneSYNCI
DEFINITION	An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.NCI
code	C37452
is someValuesFrom of	nodeID://b648967 nodeID://b648970 nodeID://b656645 nodeID://b657229 nodeID://b657232 nodeID://b660460 nodeID://b670973 nodeID://b676688

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