About: Tesetaxel     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tesetaxel
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tesetaxel
UMLS_CUI
  • C1313820
CAS_Registry
  • 333754-36-2
In_Clinical_Trial_For
  • Colorectal adenocarcinoma; unspecified solid tumor
FDA_UNII_Code
  • UG97LO5M8Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of taxane derivative.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 346914
PDQ_Closed_Trial_Search_ID
  • 346914
Chemical_Formula
  • C46H60FN3O13
Legacy_Concept_Name
  • DJ-927
FULL_SYN
  • DJ-927PTNCI-GLOSSCDR0000367408
  • DJ-927CNNCI
  • TESETAXELPTFDAUG97LO5M8Y
  • TesetaxelPTNCI
DEFINITION
  • A semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.NCI
code
  • C37451
is someValuesFrom of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 112 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software